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. 2020 Sep 4;22:201. doi: 10.1186/s13075-020-02304-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — EPZ inhibits DMM-induced subchondral bone loss in mouse tibia. a Three-dimensional images of the knee joints in each group, reconstructed using the built-in μCT software. b Structural parameters of the tibial subchondral bone, analyzed according to trabecular bone volume/tissue volume (BV/TV), trabecular thickness (Tb. Th), and trabecular separation (Tb. Sp). Data are presented as mean ± SD from 10 samples. Data were analyzed using the one-way analysis of variance with the SNK post hoc test. *P < 0.05 vs. the DMM group. ^#P < 0.05 vs. the sham group