Figure 3.

198 genes are shared between time-resolved transcriptomes of Caco-2 cells challenged by wild-type CjeCas9-producing C. jejuni strain (WT) or its isogenic ∆cas9 mutant (a) STEM analysis of Caco-2 cells transcriptomes infected by WT and its isogenic ∆cas9 mutant yielded a set of 198 genes that were significantly modulated upon infection by either strain. (b) Cytoscape network analysis (see the methods section) revealed that the proteins encoded by these genes formed a network including the cell cycle regulators JUN, FOS and p53 (encoded by the gene TP53) as central nodes.