Table 3.

Summary of extent of manual curation across the different models. GPR: gene–protein–reaction associations.

Model	P. acidi. 4875	P. acidi. 55737	P. freud	P. avidum	P. prop	P. acnes
							Reactions added	250	239	219	237	213	226
Transporters added	117	121	121	131	131	127
Reactions removed	26	22	29	21	22	19
GPR altered	139	141	107	119	111	122
Total reactions	1050	1056	933	962	977	952
Total transporters	242	241	217	229	218	231
Reactions without GPR	55	45	49	56	49	45
Transporters without GPR	103	103	109	112	115	109

Table 3 summarizes key aspects of the manual curation performed of the draft reconstructions such as the addition or removal of metabolic reactions and metabolite transporters, alterations to the gene–protein–reaction associations (GPR), and the final model size and GPR coverage.