Table 4.

Summary of extent of manual curation across the database.

Database Modifications
Reaction directionality changes	116
New reactions added to database	105
New metabolites added to database	28

Table 4 summarizes the extent of manual curation that occurred on information from the KBase database where the model was sourced from: namely, corrections to the thermodynamic bounds of reactions, corrections of compounds participating in a reaction (generally preferred over generating entirely new reactions), and the additional reactions to describe biochemistry absent from the database.