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. 2020 Oct 12;12(10):2931. doi: 10.3390/cancers12102931

Figure 1.

Figure 1

Estrogen regulates distinct protein targets in invasive lobular carcinoma (ILC) cells vs. MCF-7 invasive ductal carcinoma (IDC) cells. Reverse phase protein array (RPPA) was used to identify signaling changes after treatment with estrogen, comparing ILC models MDA MB 134VI (MM134) and SUM44PE (44PE) to IDC model MCF-7. Cells were hormone-deprived prior to treatment with 100pM estradiol (E2) for 24 h (biological triplicate). (A), RPPA targets with significant changes for E2 vs. vehicle (-E2) samples were compared per cell line (q < 0.05 for MM134 and 44PE; q < 0.25 for MCF-7; see text). (B–C), Heatmaps for fold change, E2 vs. veh (mean of biological triplicate). Gene ontology derived from DAVID database. (B), Shared/common E2-regulated targets in all three cell lines. * MCF-7 E2 vs. veh q > 0.05. (C), E2-regulated targets identified in both ILC models but not in MCF-7 cells.