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. 2020 Oct 12;12(10):2931. doi: 10.3390/cancers12102931

Figure 6.

Figure 6

High WNT4 expression is associated with activated mTOR signaling in ILC and serous ovarian cancer. (A) RNAseq z-scores used to identify tumors with high WNT4 mRNA levels from The Cancer Genome Atlas (TCGA) data. Points represent individual tumor samples; colored v gray points represent individual tumor samples with high/low WNT4. n = 354 genes differentially expressed in WNT4-high vs. -low tumors were analyzed against the MSigDB “Hallmark” genesets. (B) RNAseq z-scores were used to identify WNT4-high vs. -low tumors as in (A). (C) cBio “Enrichment” tool was used to identify differences in RPPA signals for WNT4-high vs. -low tumors (q < 0.05). (D), Mean log2 RPPA signal for WNT4-associated RPPA targets specific to OvCa. *, GSK3A/B and AKT1/2/3 are counted as individual targets in cBio but do not have unique data (n = 15 from Venn yields n = 11 unique targets). (E), Overall survival data derived from cBio “Survival” tool. High v low WNT4 as in (B).