Table 1.
The percentage of Hb species formation in response to indicated compounds calculated according to Kanias et al. [25].
| Hb Species | Control | t-BOOH | A23187 | SNC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.5 mM | 1 mM | 2 mM | 1 µM | 500 µM | ||||||||
| 1 h | 3 h | 1 h | 3 h | 1 h | 3 h | 1 h | 3 h | 1 h | 3 h | 1 h | 3 h | |
| % OxyHb | 98.0 ± 2.0 | 95.6 ± 3.0 | 66.3 ± 4.2 * | 45.3 ± 3.9 * | 30.7 ± 9.0 ** | 27.0 ± 13.6 ** | 20.9 ± 16.4 ** | 20.7 ± 15.1 ** | 97.4 ± 3.1 | 96.6 ± 3.0 | 47.2 ± 5.9 ** | 33.1 ± 3.4 ** |
| % MetHb | 1.8 ± 0.1 | 4.0 ± 2.3 | 30.6 ± 5.1 * | 49.1 ± 6.6 * | 50.5 ± 8.1 ** | 47.0 ± 11.8 ** | 58.8 ± 9.4 ** | 46.1 ± 6.6 ** | 2.3 ± 0.5 | 3.4 ± 0.6 | 50.8 ± 4.1 ** | 63.4 ± 4.6 ** |
| % HbChr | 0.2 ± 0.6 | 0.4 ± 0.2 | 4.9 ± 3.6 | 5.4 ± 2.1 | 18.8 ± 5.4 * | 25.9 ± 8.1 ** | 20.3 ± 12.8 * | 33.2 ± 9.1 ** | 0.3 ± 0.2 | 0.2 ± 0.1 | 2.5 ± 1.4 | 3.6 ± 2.5 |
Data are presented as means ± SD (n = 7), one-way ANOVA, Levene’s test < 0.05, and Tamhane T2 post hoc. * p < 0.05, ** p < 0.001, compared to corresponding control (1 h or 3 h).