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. 2020 Sep 28;10(10):1384. doi: 10.3390/biom10101384

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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NOESY cross-relaxation rates between the three resolved signals of ibuprofen and the respective molecular segments of POPC along the membrane normal in POPC (red) and in POPC/cholesterol (80/20, mol/mol) (blue) membranes in the presence of 10 mol% ibuprofen. Cross-relaxation rates for the positions marked by * were not analyzed because of a significant signal overlap of ibuprofen and POPC signals. For the ibuprofen signal at 1.8 ppm, only cross peaks for the chain region of POPC were clearly observed.