Table 5.
Relationship between TGAACA core motif mutational signature and standard clinical pathological and biological parameters.
| Parameters | Total Population (%) | Group 1 No Non-Coding Mutation |
Group 2 One or Two Non-Coding Mutations |
Group 3 Three or More Non-Coding Mutations |
p-Value * |
|---|---|---|---|---|---|
| Total population | 103 (100.0) | 39 (37.9) | 46 (44.7) | 18 (17.5) | |
| Age (years) | |||||
| ≥60 | 77 (74.8) | 29 (74.4) | 34 (73.9) | 14 (77.8) | 0.95 (NS) |
| <60 | 26 (25.2) | 10 (25.6) | 12 (26.1) | 4 (22.2) | |
| Sex | |||||
| Male | 86 (83.5) | 36 (92.3) | 40 (87.0) | 10 (55.6) | 0.0017 |
| Female | 17 (16.5) | 3 (7.7) | 6 (13.0) | 8 (44.4) | |
| Smoking status a | |||||
| Non-smoker | 28 (28.9) | 6 (17.1) | 16 (36.4) | 6 (33.3) | 0.16 (NS) |
| Smoker | 69 (71.1) | 29 (82.9) | 28 (63.6) | 12 (66.7) | |
| History of NMIBC | |||||
| No | 59 (57.3) | 27 (69.2) | 20 (43.5) | 12 (66.7) | 0.039 |
| Yes | 44 (42.7) | 12 (30.8) | 26 (56.5) | 6 (33.3) | |
| Associated pTis | |||||
| No | 94 (91.3) | 35 (89.7) | 43 (93.5) | 16 (88.9) | 0.77 (NS) |
| Yes | 9 (8.7) | 4 (10.3) | 3 (6.5) | 2 (11.1) | |
| Tumor stage | |||||
| Cis | 1 (1.0) | 1 (2.6) | 0 (0) | 0 (0) | 0.57 (NS) |
| Ta | 30 (29.1) | 11 (28.2) | 17 (37.0) | 2 (11.1) | |
| T1 | 15 (14.6) | 5 (12.8) | 6 (13.0) | 4 (22.2) | |
| T2 | 19 (18.4) | 8 (20.5) | 8 (17.4) | 3 (16.7) | |
| ≥T3 | 38 (36.9) | 14 (35.9) | 15 (32.6) | 9 (50.0) | |
| FGFR3 status | |||||
| Mutated | 28 (27.2) | 6 (15.4) | 19 (41.3) | 3 (16.7) | 0.015 |
| Not mutated | 75 (72.8) | 33 (84.6) | 27 (58.7) | 15 (83.3) | |
| PIK3CA status | |||||
| Mutated | 13 (12.6) | 2 (5.1) | 7 (15.2) | 4 (22.2) | 0.15 (NS) |
| Not mutated | 90 (87.4) | 37 (94.9) | 39 (84.8) | 14 (77.8) | |
| TERT status b | |||||
| Mutated | 79 (76.7) | 25 (65.8) | 38 (82.6) | 16 (88.9) | 0.082 (NS) |
| Not mutated | 23 (22.3) | 13 (34.2) | 8 (17.4) | 2 (33.3) | |
* Chi2 test; In bold: p-value < 0.05; a data available for 97 patients; b data available for 102 patients.