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Secretion of IL-6 (a), TNF-α (b), and IL-10 (c) increased upon LPS stimulation. IL-6 and IL-10 did so in a sustained manner over 48 h while TNF-α only showed a transient activation. The mitochondrial DNA copy number (d) decreased after 24 h and 48 h of LPS stimulation (***: p < 0.001).
