Figure 7.
Status of m6A-methylation sites of genes in neurological disorders. (A) Identification of methylated genes and their specifically methylated patterns in RNA transcripts. The red dots stand for E-SMRs, the blue dots stand for P-SMRs, and the dark yellow dots stand for CMRs. (B) IGV analysis of three representative E-SMRs that act as pathogenetic genes (Cdk5rap2, Foxp2 and Gli3) associated with neurological disorders. (C) IGV analysis of three representative P-SMRs (Psen2, Dnajc6 and Htr5a). (D) IGV analysis of eight representative CMRs (Psen1, Mapt, Chd8, Dync1h1, Fkrp, Pik3ca, Ercc6 and Mecp2) encoding neurological disease-risk genes.