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. 2020 Oct 10;9(10):2269. doi: 10.3390/cells9102269

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Elevated CD44 expression in peripheral TMPs from breast cancer patients who underwent chemotherapy. (A,B) Blood was collected from breast cancer patients at baseline, and 24 h after the first cycle of paclitaxel therapy (n = 15). The percentage of TMPs (expressing both MUC-1 and CD44) was evaluated by flow cytometry in baseline and post-chemotherapy platelet-poor plasma samples. Fold-increase of TMPs (MUC-1+/CD44+) was calculated relative to baseline levels, and found to be statistically significant (p < 0.05) using the non-parametrical Wilcoxon signed-rank test (A). Representative dot plots of the flow cytometry analysis are shown (B). * p < 0.05.