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. 2020 Oct 16;10(10):2040. doi: 10.3390/nano10102040

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Interaction of AuBSA-NPs with cells of different spheroids. (A–D) Penetration of AuBSA-NPs into HepG2 cells. (A,B) adsorption of NPs on plasmalemma, insert shows NP adsorption at high magnification. (C,D) AuBSA-NPs in late endosomes. (E,F) Penetration of AuBSA-NPs into HEK293 cells. (E) NPs on plasmalemma and in late endosome. (F) AuBSA-NPs in late endosomes and in a vesicle. 1—cytoplasm; 2—late endosomes; 3—cell outgrowths; asterisks show external space and arrows show plasmalemma. Bars correspond to 100 nm.