Table 3.
List of mitochondrial genes regulated by melatonin in nonstressed cells (Mel vs. Control) and stressed cells (MelH vs. H). The fold change and p-values are provided in Datasets S1 and S4. They are classified into different categories, and the genes that were upregulated and downregulated in each condition are listed.
| Category/Element | Mel vs. Control | MelH vs. H | ||
|---|---|---|---|---|
| Upregulated | Downregulated | Upregulated | Downregulated | |
| Complex II of ETC | SHH4 | SDH4, SDH8, SDH6 | ||
| Complex III of ETC | RIP1, CYT1, COR1, QCR2, QCR6, QCR9, QCR10, QCR8 | QCR7, QCR9 | ||
| Complex IV of ETC | COX1, COX5B | COX5A, COX10, COX15, COX4, COX8, COX12 | COX1, COX2, COX3, COX5A, COX6, COX7, COX8, COX17 | |
| Complex V of ETC | ATP3, ATP5, ATP7, ATP17, ATP14 | ATP8, ATP14, ATP15, ATP18, ATP19, ATP20 | ||
| Other genes related to ETC | RCF2 | CYC1, CYC3, CYT2, COX10, COX15, NDE1 | RCF1, CYC7, COQ10, COA1, CMC2 | ALD5, COQ1 |
| Mitochondrial protection | HSP78 | SOD2, HSP60, GPX2 | CIS1/YLR246C, GDH3, GPX1, TRX1, HYR1 | |
| Mitochondrial import | PAM16, PAM18 | TOM7, TIM8, HOT13, PAM17 | XDJ1, MSK1, YJR045C | |
| Mitochondria morphology | MIC19, MIC12, FMP30, MDV1 | MIC19, MIC26, GET1 | ||
| Mitoribosome | PPE1 | MRPL7, MRPL16, MRPL51, MEPL15, MRPL19, MRPL6, MRPS28, MRP21 | MRPL16, MRPL44, MRPL32, MRPL27, YNL122C, MRP2, MRP17, MRPS5, RSM18, MRPS8 | GEP3, MRP4 |
| Mitochondrial translation | RPO41, RMD9, RPM2, MSS116, MTG2 | CBP6, RPM2, RTC6, PET54 | MSS116, MSS51, PET111, PET9 | |
| Intergenomic signaling | COR1, QCR2, QCR6, COX5A, COX8, ATP3, ATP5, ATP7, ATP14, ATP17, BNA4, MIR1, SOD2 | COX6, COX5A, COX7, COX8, ATP14, ATP20, QCR7, SDH4 | ||
| Mitochondrial transporters | MPC3, AAC3 | MIR1, CTP1, RIM2, YAT1, OAC1 | HSP10, HXT6, OM14, MRS4, CRC1 | MMT1, MDL1, GNP1, ATM1, YHM2 |
| TCA cycle | MDH2, CIT2, SHH4 | LSC2 | CIT2, SDH4, SDH8, SDH6 | |
| Metabolism (other) | HEM13, HEM14, CHA1, ICT1, SYM1 | GUT2, ARG8, EHT1, CLD1, FOL1, UPS2, DLD1 | YHR208W, AYR1, NCE103, CPT1, HFD1, ETR1 | MAE1, HEM1 |
| Other genes ubicated in the mitochondria membrane | RDL1, ISC1 | COQ8, YGR266W, OMS1 | ZEO1, OM45, RDL1 | YBR238C, UTH1 |
| Protein modification | MAS2 | PTH2, ISA2 | YTA12, UBX2, PTC5, YME1 | |
| Other | ISU1, MMF1, VPS73 | CIR2, UBP16, PUF3, AIF1, AIM36, MIX17, POS5, DRE25 | YBL059W, YPT7, FYV4, ISU2, YSC83, CIR1, AIM19, VPS1, YCR028C-A, ATG9, FMC1, YSP2, MIX14, FMP33, HMF1, ECM10 | PKP1, CAF4 |