Table 2.
Number of ARV and Non-ARV Treatments Affected by a Drug Interaction in 2016 and 2012
| 2016 | 2012 | |||
|---|---|---|---|---|
| Treatment | Red Flag Interactions (n = 85), No. (%) | Orange Flag Interactions (n = 1412), No. (%) | Red Flag Interactions (n = 68), No. (%) | Orange Flag Interactions (n = 1070), No. (%) |
| ARV | ||||
| Atazanavir | 9 (10.6) | 63 (5.5) | 25 (36.8) | 169 (15.8) |
| Darunavir | 17 (20.0) | 128 (11.3) | 3 (4.4) | 76 (7.1) |
| Ritonavir | 23 (27.1) | 177 (15.6) | 30 (44.1) | 314 (29.3) |
| Lopinavir | 5 (5.9) | 21 (1.9) | 9 (13.2) | 90 (8.4) |
| Fosamprenavir | - | 2 (0.2) | - | 22 (2.1) |
| Saquinarir | - | - | - | 1 (0.1) |
| Darunavir/cobicistat | 6 (7.1) | 45 (4.0) | - | - |
| Etravirine | 1 (1.2) | 42 (3.7) | - | 39 (3.6) |
| Efavirenz | - | 72 (6.3) | - | 93 (8.7) |
| Zidovudine | - | 1 (0.1) | - | 12 (1.2) |
| Rilpivirine | 9 (10.6) | 23 (2.0) | 1 (1.5) | - |
| Nevirapine | - | 111 (9.8) | - | 82 (7.7) |
| Abacavir | - | 11 (1.0) | - | 3 (0.3) |
| Didanosine | - | - | - | 1 (0.1) |
| Emtricitabine | - | 13 (1.1) | - | 44 (4.1) |
| Lamivudine | - | 33 (2.9) | - | 26 (2.4) |
| Tenofovir | - | 51 (4.5) | - | 58 (5.4) |
| Maraviroc | - | 9 (0.8) | - | 4 (0.4) |
| Dolutegravir | - | 140 (12.3) | - | - |
| Raltegravir | - | 31 (1.7) | - | 36 (3.4) |
| Emtricitabine/tenofovir alafenamide fumarate/elvitegravir/cobicistat | 6 (7.1) | 54 (4.8) | - | - |
| Emtricitabine/tenofovir disoproxil fumarate/elvitegravir/cobicistat | 9 (10.6) | 110 (9.7) | - | - |
| Non-ARV | ||||
| Ear, nose, and throat drugs | 5 (5.9) | 5 (0.4) | 6 (8.8) | 5 (0.5) |
| Osteoarticular drugs | 1 (1.2) | 57 (5.0) | 2 (2.9) | 48 (4.5) |
| Cardiovascular drugs | 35 (41.2) | 272 (23.9) | 21 (30.9) | 250 (23.4) |
| Gastrointestinal drugs | 17 (20.0) | 21 (1.9) | 19 (27.9) | 18 (1.7) |
| Respiratory drugs | 24 (28.2) | 21 (1.9) | 18 (16.5) | 33 (3.1) |
| Hemostasis drugs | 1 (1.2) | 46 (4.0) | - | 43 (4.0) |
| CNS agents | 2 (2.4) | 255 (22.4) | 2 (2.9) | 305 (28.5) |
| Analgesics | - | 34 (3.0) | - | 46 (4.3) |
| Obstetrics & gynecology | - | 27 (2.4) | - | 41 (3.8) |
| Immunity | - | 19 (1.7) | - | 10 (0.9) |
| Anti-infectives | - | 58 (5.1) | - | 82 (7.7) |
| Antineoplastic agents | - | 2 (0.2) | - | 1 (0.1) |
| Others drugs | - | 8 (0.7) | - | 5 (0.5) |
| Genitourinary drugs | - | 3 (0.3) | - | 12 (1.1) |
| Dietary supplements | - | 153 (13.5) | - | 32 (3.0) |
| Hormone drugs | - | 156 (13.7) | - | 139 (13.0) |
Abbreviations: ARV, antiretroviral; CNS, central nervous system.