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. 2020 Jul 31;37(8):157. doi: 10.1007/s11095-020-02882-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The median estimate of the E_max parameter with 2.5th and 97.5th percentiles for dose-response on end-of-study data and dose-response MMRM, stratified by time-course of the drug effect and ED₅₀. The true E_max is also shown in the gray line. The y axis was cut at −5 for visibility, error bars for higher true ED₅₀ extend well below the range of the graph