Table 2. .
Clinical Data of 177 Patients in France (2008–2017): Comparison With Data From 5 Previously Reported Case Seriesa
| Data | Ref [11] | Ref [8] | Ref [22] | Ref [7] | Ref [19] | Our Study |
|---|---|---|---|---|---|---|
| Country | USA | Sweden | Turkey | Spain | France | France |
| Number of patients (M/F) | 88 (3.5) | 234 (1.05) | 205 (0.55) | 142 (0.59) | 101 (1.37) | 177 (2.28) |
| Study period | 1949–1979 | 2000–2004 | 1988–1998 | 1997–1998 | 2006–2010 | 2008–2017 |
| Age ranges (means) | 2–82 (NI) | 1–88 (48.3) | 5–75 (NI) | 14–82 (52) | 5–95 (52) | 2–89 (47.4) |
| Main sources of infection | Hares | Mosquitos | Water | Hares | Hares | Hares |
| Fever | 85 | 83 | 66 | 90.8 | 67.3 | 85.0 |
| Headache | 45 | 32 | 15 | 9.9 | NA | 13.4 |
| Myalgia | 31 | NA | 6 | 25.4 | 20.8 | 25.5 |
| Arthralgia | 15 | NA | NA | 14.8 | 16.8 | 21.2 |
| Cough | 38 | 25 | NA | 24 | 5.9 | 9.2 |
| Sore throat | 15 | 3 | 58.5 | 16.9 | 15.8 | 7.0 |
| Nausea and/or vomiting | 17 | 23 | NA | 24 | 5.9 | 2.8 |
| Diarrhea | 10 | 9 | NA | 2.1 | 3.9 | 6.4 |
| Inoculation lesion | 59 | 88 | NA | 61.4 | 31.7 | 35.6 |
| Secondary dermatological lesion | 5.7 | 29.9 | 14 | 17.6 | 2.9 | 11.9 |
| Lymphadenopathy | 86 | 91.9 | 85 | 69.7 | 69.3 | 87.8 |
| Pharyngitis | 23.8 | NA | 29 | 16.2 | 19.8 | 4.2 |
| Conjunctivitis | NA | NA | 2 | NA | 2.9 | 3.5 |
| Hepatosplenomegaly | 16 | NA | 2 | NA | 2.9 | 5.6 |
| Worsening of condition | NA | NA | NA | 38.7 | 3.9 | 33.8 |
Abbreviations: M/F, male/female sex ratio; NA, no data available; Ref, reference.
aAll data are given as percentages unless otherwise specified.