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. 2020 Nov 6;8(2):e001355. doi: 10.1136/jitc-2020-001355

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Tumor-infiltrating T cells are associated with distant progression in soft tissue sarcoma. (A) Characteristics of the retrospectively analyzed cohort. (B) Representative H&E photomicrographs of TIL scores. (C) Distribution of mean TIL scores for the cohort. (D) Representative immunohistochemical photomicrographs of high and low staining for CD3, CD8, and TIGIT. (E) Distribution of mean expression scores (H-score) for CD3, CD8, and TIGIT for the cohort. Kaplan-Meier curves of distant recurrence-free survival (DRFS) stratified by (F) TIL score, (G) CD3 score, and (H) CD8 score. (I) Strong positive correlation between CD3 expression and TIL score. (J) Absence of association between DRFs and TIGIT score by Kaplan-Meier analysis. (K) Strong positive correlation between TIGIT expression and TIL score. Significance of Kaplan-Meier analysis determined by log-rank test. Correlations determined by two-tailed Spearman coefficient. TIL, tumor-infiltrating lymphocyte.