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. 2020 Nov 6;8(2):e001355. doi: 10.1136/jitc-2020-001355

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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CD56^dim subset is the predominate NK cell within soft tissue sarcomas and expresses higher TIGIT. (A) Representative flow cytometry gating showing the CD56^bright and CD56^dim NK cell populations in the peripheral blood (left) and tumor (right). (B) No difference in proportion of NK cell subsets between the periphery and tumor. (C) Within the peripheral blood, CD56^dim NK cells expressed higher levels of activation marker CD69 compared with CD56^bright NK cells (p=0.015), which was not evident within the tumor. (D) Within the periphery (p<0.0001) and within the tumor (p=0.01), TIGIT expression was significantly higher on CD56^dim NK cells compared with CD56^bright NK cells. (E) CD56^dim NK cell subset significantly increases TIGIT expression by MFI within the tumor (p=0.03). Mean±SEM. P values determined using paired Student’s t-test or Wilcoxon test. MFI, median fluorescence intensity; NK, natural killer.