Figure 1.

Effect of chrysin on the nociceptive response induced by formalin. Mice were administered orally with chrysin (from 10 to 100 mg/kg) for 30 min prior to the formalin (5%, 10 μl) injection subcutaneously into the plantar aspect of the left side hind paw. The cumulative response time of licking, biting and shaking the injected paw was measured during the period of 0–5 min (1st phase) (A) and 20–40 min (2nd phase) (B). The vertical bars indicate the standard error of the mean. The number of animals used for each group was 8–10 (*p < 0.05; **p < 0.01, compared with control group).