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Non-reversible peptide stapling increases peptide stability and protease resistance. MALDI-ToF spectra of biotin-TAxI (A), biotin-TAxI S-S (B), and biotin-TAxI BP (C) peptides incubated in normal mouse serum for 1hr, 2hr, 4hr, 8hr, 24h, and 48 hr. Primary peaks of each peptide-fragment and molecular weight is shown. Bottom: predicted amino acid sequence of degradation products, based on molecular weight.
