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. 2020 Aug 6;11(10):1168–1177. doi: 10.1039/d0md00203h

Table 7. Mouse efficacy model of VL for 48 and 50.

Compound Dosing regimen % Suppression of parasite load
48 30 mg kg–1b.i.d. for 5 days PO 60
48 100 mg kg–1b.i.d. for 5 days PO 98
50 25 mg kg–1b.i.d. for 5 days PO 17
50 50 mg kg–1b.i.d. for 5 days PO 57