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. 2020 Oct 22;20(6):247. doi: 10.3892/etm.2020.9377

Figure 2.

Figure 2

PKM2 may be a target gene for miR-122 in regulating PCa. The expression of PKM2 (A) mRNA and (B) protein in LNCaP and LNCaP/Docetaxel cells was detected. ***P<0.001. (C) The correlation between miR-122 and PKM2 in primary PCa cells was analyzed by Pearson's correlation coefficient analysis. (D) The binding site between the 3'-UTR of PKM2 and miR-122 was predicted by TargetScan. Following miR-122 inhibitor or mimic treatment, the luciferase activity of the PKM2 reporter was detected, and PKM2 (E) mRNA and (F) protein expression was detected. *P<0.05; **P<0.01 and ***P<0.001 vs. NC. miR-122, microRNA-122; NC, negative control; 3'-UTR, 3'-untranslated region.