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. 2017 Jan 13;24(4):697–708. doi: 10.1093/jamia/ocw168

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© The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For Permissions, please email: journals.permissions@oup.com

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Figure 1. — Data source and reference set for ADR signal detection and validation. (A) Inclusion and exclusion steps that yielded 101 precautionary study drugs. (B) The RS-ADR was created by standard vocabulary-based mapping of drug-ADR associations between SIDER 2 and EHRs. (C) Composition of ADRs annotated with MedDRA PTs detectable by MetaNurse and MetaLAB for all 996 SIDER 2 drugs (right panel) and 101 precautionary study drugs (left panel). UN, United Nations.