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. 2020 Aug 19;11(10):1210–1225. doi: 10.1039/d0md00153h

Table 2. Optimization of the esterification reaction.

Entry	Solvent	LA (x, M)	LB (x, M)	V (mL)	T (°C)	Yield ^a (%)
1	DMF	3a, 4a; 0.1, 0.1	DCC, DMAP; 0.1, 0.001	15	25	11 ^b
2	CH₃CN	3a, 4a; 0.1, 0.1	DCC, DMAP; 0.1, 0.001	15	25	13 ^b
3	CH₃CN	3a, 4a; 0.1, 0.1	DCC, DMAP; 0.1, 0.001	5	25	17 ^b
4	CH₃CN	4a; 0.1	3a, DCC, DMAP; 0.1, 0.1, 0.001	5	25	70 ^b ^, ^c
5	CH₃CN	4a; 0.1	3a, DCC, DMAP; 0.1, 0.1, 0.001	5	50	74 ^b ^, ^c
6	CH₃CN	4a; 0.1	3a, T3P, TEA; 0.1, 0.1, 0.2	5	25	82
7	CH₃CN	4a; 0.1	3a, T3P, TEA; 0.1, 0.1, 0.2	10	25	89 (85)
8	CH₃CN	4a; 0.1	3a, T3P, TEA; 0.1, 0.1, 0.2	10	50	76

^aNMR yields. Isolated yield between brackets.

^bReactor blockage.

^cUltrasonic irradiation.