Table 4. Comparative study of the optimal synthetic macamides against natural macamides and the positive control C87 on TNF-α.
| No. | Derivatives | Viability (CC50 μM) THP-1 cells | TNF-α inhibition (IC50 μM) THP-1 cells | clog P a |
| 4a |
|
90.1 ± 1.27 | 0.009 ± 0.001 | 9.09 |
| 4b |
|
80.9 ± 1.96 | 0.05 ± 0.001 | 9.19 |
| 4c |
|
71.5 ± 1.13 | 0.06 ± 0.001 | 8.75 |
| 1 |
|
>100 | 3.54 ± 0.02 | 8.79 |
| 2 |
|
>100 | 1.77 ± 0.07 | 6.58 |
| C87 |
|
10.81 ± 1.23 | 0.11 ± 0.01 | 4.57 |
aValues of clog P were calculated by DataWarrior.271 = N-oleoyldopamine; 2 = N-(2-hydroxyethyl)-7Z,10Z,13Z,16Z-docosatetraenamide.