Table 3.
| 8th Edition | 7th Edition | |||
|---|---|---|---|---|
| M Category | Anatomic Site | LDH Level | Anatomic Site | LDH Level |
| M0 | No evidence of distant metastasis | Not applicable | No distant metastases | |
| M1 | Evidence of distant metastasis | Evidence of distant metastasis | ||
| M1a | Distant metastasis to skin, soft tissue including muscles, and/or nonregional lymph node | Not recorded or unspecified | Distant skin, subcutaneous, or nodal metastases | Normal |
| M1a(0) | Not elevated | – | – | |
| M1a(1) | Elevated | – | – | |
| M1b | Distant metastasis to lung with or without M1a sites of disease | Not recorded or unspecified | Lung metastases | Normal |
| M1b(0) | Not elevated | – | – | |
| M1b(1) | Elevated | – | – | |
| M1c | Distant metastasis to non-CNS visceral sites with or without M1a or M1b sites of disease | Not recorded or unspecified | All other visceral metastases Any distant metastasis | Normal Elevated |
| M1c(0) | Not elevated | – | – | |
| M1c(1) | Elevated | – | – | |
| M1d | Distant metastasis to CNS with or without M1a, M1b, or M1c sites of disease | Not recorded or unspecified | – | – |
| M1d(0) | Not elevated | – | – | |
| M1d(1) | Elevated | – | – | |
LDH, lactate dehydrogenase; –, No counterpart in AJCC 7th Edition.
Adapted from and used with permission of the American Joint Committee on Cancer (AJCC), Chicago, Illinois. The original and primary source for this information is the AJCC Cancer Staging Manual, 8th Edition (2017), published by Springer International Publishing (Gershenwald JE, Scolyer RA, Hess KR, et al. Melanoma of the Skin. In: Amin AB, Edge SB, Greene, FL, et al. (Eds). AJCC Cancer Staging Manual. 8th Ed. New York: Springer; 2017:563–585).
Adapted from and used with permission of the American Joint Committee on Cancer (AJCC), Chicago, Illinois. The original and primary source for this information is the AJCC Cancer Staging Manual, 7th Edition (2009), published by Springer Verlag (Balch CM, Gershenwald JE, Soong SJ, et al. Melanoma of the Skin. In: Edge SB, Byrd D, Compton C, et al. (Eds). AJCC Cancer Staging Manual. 7th Ed. New York: Springer; 2009: 325–344).