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. 2020 Apr 10;10(4):148. doi: 10.3390/metabo10040148

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Top differentially regulated metabolites during endotoxemia. Top 25 most significantly (according to p-value) regulated metabolites at T = 0 (just before LPS administration), 1, 2, 4, and 8 h post-LPS administration compared with baseline (one hour before LPS administration) in the control group. Blue color indicates a decrease compared with baseline (this top 25 only comprises decreased metabolites). p-values were calculated using paired t-tests with multiple-testing correction (Benjamini–Hochberg false discovery rate [FDR]).