Table 2. Baseline inflammatory biomarker profile.

Inflammatory biomarkers	Non-frail	Frail	Very-frail	Unadjusted	Adjusted
	n = 50	n = 40	n = 51	p value	p value
TNF-α, pg/ml,	21.16	25.54	28.71	0.003	0.046
median (range)	(25.33–30.97)	(24.23–28.03)	(27–32.78)
IL-8, pg/ml,	19.91	9.69	22.31	<0.001	0.033
median (range)	(11.34–24.95)	(6.66–17.95)	(12.63–32.98)
IL-6, pg/ml,	12.22	9.19	11.08	0.118	0.421
median (range)	(8.03–16.24)	(7.73–11.05)	(8.38–18.52)
CRP, mg/l,	12.13	6	63	0.01	0.003
median (range)	(4.97–28.5)	(3.27–60.4)	(12.10–104.5)

TNF-α, tumor necrosis factor-α; IL-8, interleukin-8; IL-6, interleukin-6; CRP, C-reactive protein.

Adjusted p value obtained after adjustment for age.