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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: Nat Biotechnol. 2020 Jun 15;38(11):1317–1327. doi: 10.1038/s41587-020-0555-7

Extended Data Fig. 9. Influence of chromatin state on CRISPR-Cas9 genome-wide off-target activity.

Extended Data Fig. 9

a, Barplots showing the enrichment of individual epigenetic feature in GUIDE-seq (n=1,196), CHANGE-seq (n=11,000) and Cas-OFFinder (n=11,000). Statistical significance was calculated using two-tailed Welch’s t-test. Error bars indicate 95% confidence interval, estimated from 1000 bootstrap samples. b, Heatmap showing fold enrichment for various genomic annotations computed by ChromHMM for validation of chromatin state annotations. Darker colors represent higher fold enrichment.