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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: Nat Biotechnol. 2020 Jun 15;38(11):1317–1327. doi: 10.1038/s41587-020-0555-7

Extended Data Fig. 2. Schematic comparison of CIRCLE-seq and CHANGE-seq workflows.

Extended Data Fig. 2

CHANGE-seq eliminates the requirement for specialized equipment for physical DNA shearing along with 9 additional enzymatic or purification steps. The simplified workflow substantially streamlines the process, decreases the requirement of input genomic DNA for circularization by approximately 5-fold and reduces the number of reactions to process each sample by 10- to 20-fold to a single reaction per sample.