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. 2020 Oct 22;9:e61496. doi: 10.7554/eLife.61496

Figure 5. Models for substrate recognition, engagement, and unfolding by ClpXP.

Figure 5.

Top. A substrate with a relatively long degron (~20 residues) is recognized and subsequent ATP-dependent power strokes then move the degron deeper into the ClpX channel in the intermediate complex, and then the engaged complex, from which unfolding occurs. Bottom. A substrate with a short degron (~5 residues) forms a recognition complex that is engaged and can therefore carry out direct ATP-dependent unfolding.