Figure 1. Induction of cytotoxicity and apoptosis by quetiapine in HCC. Cell viability of (A) SK-Hep1 and (B) Hep3B after quetiapine treatment are performed by MTT assay. (C) Annexin/PI staining pattern and (D) quantification data by flow cytometry after quetiapine treatment are displayed. After quetiapine treatment in HCC, (E) cell cycle analysis, (G) cleaved caspase-3 and (I) cleaved PARP-1 are also detected. Quantification results of (F) sub-G1, (H) cleaved caspase-3 and (J) cleaved PARP-1 are displayed. *p<0.05, **p<0.01 vs. 0 μM quetiapine.
