Figure 4. WD-induced renal inflammation is exacerbated in TRPV1 knockout mice. Kidney slices from WT and TRPV1–/– mice fed with western (WD) or normal (CON) diet for 23 weeks were subjected to ischemia (I, incubated with 99% N2) or a control condition (C,incubated with 95% O2-5% CO2). Malondialdehyde (MDA, A), IL-6 (B), and MCP-1 (C) levels in the kidneys were measured. Values are mean±SEM (n=7-8). *p<0.05 vs. WT-CON-c; †p<0.05 vs. TRPV1–/–- CON-c; ‡p<0.05 vs. WT-WD-c; #p<0.05 vs. TRPV1–/–-WD.
