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. 2020 Nov;98(5):1193–1209. doi: 10.1016/j.kint.2020.05.042

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© 2020 International Society of Nephrology. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Specific deletion of Ednrb from myeloid cells has a biphasic effect on the blood pressure (BP) response to angiotensin II (ANG II) and promotes long-term natriuresis. (a) Systolic and diastolic BP of Ednrb^lox/lox and LysM-Cre Ednrb^lox/lox mice during 6 weeks of ANG II infusion. (b) Urinary sodium excretion over this 6-week period. (c) Expression of cortical and medullary α epithelial sodium channel (ENaC) and endothelin-B (ET_B) receptor in Ednrb^lox/lox and LysM-Cre Ednrb^lox/lox mice at baseline and after 6 weeks of ANG II. Data represent mean ± SEM of n = 5–7 mice/group. ∗P < 0.05 and ∗∗∗P < 0.001 for baseline compared with week 6 within the same genotype; ^$P < 0.05 for one genotype compared with the other at the same time point. Between-group comparisons were performed with 2-way analysis of variance.

Specific deletion of Ednrb from myeloid cells has a biphasic effect on the blood pressure (BP) response to angiotensin II (ANG II) and promotes long-term natriuresis. (a) Systolic and diastolic BP of Ednrb^lox/lox and LysM-Cre Ednrb^lox/lox mice during 6 weeks of ANG II infusion. (b) Urinary sodium excretion over this 6-week period. (c) Expression of cortical and medullary α epithelial sodium channel (ENaC) and endothelin-B (ET_B) receptor in Ednrb^lox/lox and LysM-Cre Ednrb^lox/lox mice at baseline and after 6 weeks of ANG II. Data represent mean ± SEM of n = 5–7 mice/group. ∗P < 0.05 and ∗∗∗P < 0.001 for baseline compared with week 6 within the same genotype; ^$P < 0.05 for one genotype compared with the other at the same time point. Between-group comparisons were performed with 2-way analysis of variance.