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(A) In vivo B-mode US images and (B) echo intensity of tumors before and after laser irradiation (808 nm, 1 W cm−2, 5 min) for IRP NPs or IR NPs (*p<0.05). (C) In vivo CEUS-mode US images and (D) echo intensity of tumors before and after laser irradiation (808 nm, 1 W cm−2, 5 min) for IRP NPs or IR NPs (*p<0.05). (E) TEM examination of mouse tumor tissue after injection of IRP NPs upon 808 nm laser irradiation with a lot of microbubbles generation, indicated with yellow arrows.
