Figure 3.

The effects of keratin 23 (KRT23) on epithelial-to-mesenchymal transition (EMT) progress. (a, b) The Gene Set Enrichment Analysis (GSEA) of EMT in 154 samples exhibited high KRT23 expression and in the remaining 154 samples exhibited low KRT23 expression, which indicated that the high KRT23 expression was related to EMT. (c) The expression of EMT markers was detected by Western blotting analysis. Knockdown of KRT23 increased the expression level of E-cadherin but reduced the expression levels of N-cadherin, Snail, and Twist when compared with the control group.