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. 2020 Nov 10;115(6):65. doi: 10.1007/s00395-020-00824-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Effect of PCSK9 knockout on basal cardiac function of isolated and perfused mice hearts. Hearts from PCSK9^−/−-mice were isolated and transferred to a Langendorff perfusion system. a Left ventricular developed pressure (LVDP) in mmHg (n = 12), b dLVP/dt_max (mmHg/s) (n = 13) and c dLVP/dt_min (mmHg/s) (n = 13) (at the beginning of the stabilization phase) are shown as mean ± SD. Statistical analysis was performed by unpaired t-test for (a) and (b) as well as Mann–Whitney test for (c). *p ≤ 0.05