Fig. 1.

Grey and white matter TPMs in cohort 1. TPMs were similar to one another but notably the default template has sharper definition of tissue probability relative to the custom templates. The CerebroMatic grey matter TPMs had higher intensity at the edge of the brain. It is also notable that in the Default and TOM8 TPMs, relative to COM, subcortical structures are incorrectly classified as white matter. Although only grey and white matter tissue classes are shown, each 6-volume TPM also included a cerebrospinal fluid volume, and 3 background classes.