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. 2020 Nov 9;11(11):961. doi: 10.1038/s41419-020-03158-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Positive correlation between CD44 mRNA and genes involved in the caspase-1/IL1B pathway, such as CASP1, NLRP3, and IL1B. Relevant data were extracted from UCSC Xena for correlation analysis. b Positive correlation between CD44 mRNA and genes involved in the caspase-1/IL1B pathway, such as CASP1, NLRP3, and IL1B. Relevant data were extracted from GEPIA for correlation analysis. c Expression of CD44 mRNA and genes involved in the caspase-1/IL1B pathway in tumor or non-tumor tissues. Relevant data were extracted from GEPIA. “T” represents tumor tissues referred to red column. d mRNA expression of genes involved in the caspase-1/IL1B pathway in HCC tissues with high or low CD44 mRNA expression. n = 50. e, f Representative images of IHC staining CD44s, NLRP3, caspase-1, and IL1B in HCC samples and IHC scores were analyzed. Scale bars, 100 µm. Data are means ± SEM from 3 independent experiments, * means p < 0.05, ** means p < 0.01, *** means p < 0.001 by unpaired student t test.