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. 2020 Nov 9;10:19295. doi: 10.1038/s41598-020-76343-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Symptom scores for the four groups. Group M was the model control group, for which the score was significantly higher than that of the healthy control group N (p < 0.05). Groups A and B were the model treatment groups. With the extension of the treatment time, the symptom score gradually decreased. Compared with the score of group M, there was a significant decrease in the score starting on the 4th day (p < 0.05), but the difference between the two groups was not obvious (p > 0.05).