Table 1.

Toxicity categories used in the phase I study reports examined, as per the Common Terminology Criteria for Adverse Events, version 4.0.

Toxicity category	Common human toxicities	Common animal toxicities
Cardiovascular	Hypertension, tachycardia, bradycardia, dyslipidemia	Tachycardia, bradycardia
Cutaneous	Rash, alopecia	Rash, fur discoloration
Endocrine	Diabetes	Increase in endocrine system organs
Gastrointestinal	Nausea, vomiting, diarrhoea	Loose stool
General	Fatigue, fever, chills	Decreased activity
Haematologic	Neutropenia, thrombocytopenia	Changes in red blood cells or white blood cells
Hepatic	Changes in alanine transaminase or aspartate transaminase	Changes in alanine transaminase or aspartate transaminase
Metabolic	Anorexia, decreased appetite, hyperglycaemia	Decreased food consumption
Musculoskeletal	Muscle pain, back pain	Awkward gait, hunched posture
Neurologic/psychiatric	Headache, insomnia	Tremors
Ocular	Blurred vision	Bloody tears
Renal	Changes in creatinine or blood urea nitrogen	Blood in urine
Respiratory	Cough, shortness of breath	Laboured breathing