Table 1.
Demographics and clinical characteristics of 329 patients with severe community-acquired pneumonia
| Patient characteristics | All patients (n = 329) |
|---|---|
| Age, years (median, IQR) | 64 (49–71) |
| Female | 122 (37.1%) |
| Comorbidity | |
| Immunocompromised statusa | 65 (19.8%) |
| CVD | 59 (17.9%) |
| Chronic obstructive pulmonary disease | 55 (16.7%) |
| Neoplastic disease | 48 (14.6%) |
| Diabetes mellitus | 41 (12.5%) |
| Renal disease | 37 (11.2%) |
| Bronchiectasis | 24 (7.3%) |
| Cerebrovascular disease | 19 (5.8%) |
| Prior antibiotic use | |
| Received antimicrobials in the 72 h prior to bronchoscopy | 280 (85.1%) |
| Clinical metrics | |
| HFNC or noninvasive ventilation | 106 (32.2%) |
| Intubation and invasive ventilation | 223 (67.8%) |
| ECMO | 19 (5.8%) |
| Vasopressors | 156 (47.4%) |
| APACHE III score | 20.5 ± 4.1 |
| Pneumonia severity index | 145.2 ± 17.8 |
| PaO2/FiO2 ratio | 108, 71–129.5 |
| Total 30-day mortality | 145 (44.1%) |
Data are number (%) of patients, median (interquartile range), or mean ± standard deviation
CVD cardiovascular disease, HFNC high-flow nasal cannula, ECMO extracorporeal membrane oxygenation
aImmunosuppressive drugs, hematologic malignancy, solid tumor with either neutropenia or chemotherapy, inherited immunodeficiency syndromes. AIDS patients were not included in this study