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. 2020 Nov 9;11:5671. doi: 10.1038/s41467-020-19401-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Expression profile (log CPM – Count Per Million normalised read count) of the 5 datasets of normal tongue samples²³. Graph represents the average of CPM values; x-axis is divided in 3 categories: low, medium and high expression genes. b Pie-chart with the number of expressed genes in each category of genes mutated in hyperplastic samples. c Total number of samples and mutated genes in medium and long-treated hyperplasias and in invasive SCC before (left panels) and after (right panels) filtering for the genes medium to highly expressed in the tongue. d Top 10 KEGG pathways enriched in tongue expressed genes mutated in medium and long treated hyperplasias and in invasive SCC. The number of mutated genes in the pathway is indicated as well as the total number of genes in the pathway.