Table 1.
Clinicopathological associations of DKC1 protein nuclear and nucleolar expression in Nottingham cohort.
| Parameters | DKC1 nuclear protein expression | Adjusted p value | DKC1 nucleolar protein expression | Adjusted p value | ||||
|---|---|---|---|---|---|---|---|---|
| Number (%) | Mean rank | p value | Number (%) | Mean rank | p value | |||
| Patient age | ||||||||
| ≤50 | 348 (38) | 497.8 | 0.003 | 0.027 | 348 (38) | 477.3 | 0.09 | 0.27 |
| >50 | 580 (62) | 444.5 | 580 (62) | 456.8 | ||||
| Tumour size | ||||||||
| ≤2 cm | 575 (62) | 446.7 | 0.009 | 0.7 | 575 (62) | 452.7 | 0.01 | 0.04 |
| >2 cm | 353 (38) | 493.4 | 353 (38) | 483.7 | ||||
| Lymphovascular invasion | ||||||||
| Negative | 635 (68) | 447.9 | 0.005 | 0.012 | 635 (68) | 463.1 | 0.71 | 0.71 |
| Positive | 293 (32) | 500.4 | 293 (32) | 467.7 | ||||
| Axillary nodal stage | ||||||||
| Stage 1 | 572 (62) | 461.6 | 0.35 | 0.35 | 572 (62) | 464.7 | 0.1 | 0.2 |
| Stage 2 | 261 (28) | 457.4 | 261 (28) | 451.7 | ||||
| Stage 3 | 95 (10) | 501.1 | 95 (10) | 497.8 | ||||
| Nottingham prognostic index | ||||||||
| Good | 281 (31) | 379.3 | 3.5 × 10−9 | <0.0001 | 281 (31) | 416.8 | 0.000004 | <0.0001 |
| Moderate | 489 (53) | 492.1 | 489 (53) | 476.5 | ||||
| Poor | 150 (16) | 509.4 | 150 (16) | 490.2 | ||||
| IHC subtypes | ||||||||
| ER+/HER2− low proliferation | 390 (42) | 389.4 | 1.5 × 10−10 | <0.0001 | 390 (42) | 406.3 | 9.2 × 10−21 | <0.0001 |
| ER+/HER2− high proliferation | 272 (30) | 521.1 | 272 (30) | 453.1 | ||||
| HER2+ | 115 (13) | 504.8 | 115 (13) | 531.7 | ||||
| Triple negative | 140 (15) | 494.8 | 140 (15) | 557.6 | ||||
| Histological subtypes | ||||||||
| Lobular | 63 (7) | 383.9 | 4.9 × 10−7 | <0.0001 | 63 (7) | 393.7 | 7.5 × 10−7 | <0.0001 |
| Tubular | 128 (14) | 357.1 | 128 (14) | 409.1 | ||||
| No special type (NST) | 623 (67) | 497.4 | 623 (67) | 486.3 | ||||
| Mixed NST and lobular | 55 (6) | 440.9 | 55 (6) | 416.9 | ||||
| Other special type | 59 (6) | 458.4 | 59 (6) | 474.1 | ||||
| Tumour grade | ||||||||
| Grade 1 | 105 (11) | 269.1 | 9.8 × 10−20 | <0.0001 | 105 (11) | 402.6 | 7.8 × 10−17 | <0.0001 |
| Grade 2 | 392 (42) | 442.9 | 392 (42) | 421.8 | ||||
| Grade 3 | 432 (47) | 532.6 | 432 (47) | 519.4 | ||||
| Nuclear pleomorphism | ||||||||
| Score 1 | 10 (1) | 224.5 | 6.9 × 10−9 | <0.0001 | 10 (1) | 375.5 | 2.8 × 10−10 | <0.0001 |
| Score 2 | 239 (26) | 382.8 | 239 (26) | 396.3 | ||||
| Score 3 | 669 (73) | 490.4 | 669 (73) | 483.3 | ||||
| Mitosis | ||||||||
| Score 1 | 421 (46) | 385.2 | 4.9 × 10−16 | <0.0001 | 421 (46) | 411.1 | 6.6 × 10−15 | <0.0001 |
| Score 2 | 188 (20) | 476.1 | 188 (21) | 468.5 | ||||
| Score 3 | 308 (34) | 549.3 | 308 (33) | 518.7 | ||||
| Tubule formation | ||||||||
| Score 1 | 46 (5) | 296.7 | 0.000007 | 0.0006 | 46 (5) | 395.8 | 0.000012 | 0.0001 |
| Score 2 | 259 (28) | 436.9 | 259 (28) | 425.1 | ||||
| Score 3 | 613 (67) | 481.2 | 613 (67) | 478.9 | ||||
| Nucleoli | ||||||||
| Score 1 | 300 (39) | 346.2 | 0.0001 | 0.025 | 300 (39) | 333.7 | 7.8 × 10−33 | <0.0001 |
| Score 2 | 334 (43) | 411.6 | 334 (43) | 383.5 | ||||
| Score 3 | 143 (18) | 425.7 | 143 (18) | 517.9 | ||||
P values in bold means statistically significant.