Table 3.
Multivariate Cox regression analysis results for predictors of breast-cancer-specific survival in Nottingham cohort.
| Models | Parameters | Hazard ratio (HR) | 95% confident interval (CI) | Significance P value | Adjusted P value | |
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
| (A) | DKC1 nuclear protein expression | 2.037 | 1.373 | 3.023 | 0.000411 | 0.001 |
| Tumour size | 1.445 | 1.047 | 1.995 | 0.025 | 0.025 | |
| Nodal stage | 2.036 | 1.664 | 2.492 | 5.1 × 10−12 | <0.0001 | |
| Grade | 1.426 | 1.079 | 1.885 | 0.013 | 0.026 | |
| (B) | DKC1 nucleolar protein expression | 1.218 | 0.832 | 1.802 | 0.325 | 0.325 |
| Tumour size | 1.481 | 1.072 | 2.045 | 0.017 | 0.034 | |
| Nodal stage | 2.068 | 1.69 | 2.532 | 1.9 × 10−12 | <0.0001 | |
| Grade | 1.52 | 1.148 | 2.012 | 0.003 | 0.009 | |
| (C) | DKC1 combinatorial protein expression | 2.746 | 1.484 | 5.083 | 0.001 | 0.003 |
| Tumour size | 1.642 | 0.922 | 2.922 | 0.092 | 0.184 | |
| Nodal stage | 2.018 | 1.411 | 2.888 | 0.000123 | 0.0005 | |
| Grade | 1.037 | 0.637 | 1.69 | 0.883 | 0.883 | |
P values in bold means statistically significant.