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. 2020 Nov 9;10:19381. doi: 10.1038/s41598-020-76355-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative analysis of AAC(6′)-Ib activity in presence of amikacin (substrate) and amikacin-adjuvant combinations. In presence of amikacin as a substrate as well as positive control, the enzyme showed the highest activity (red line) through acetylation (natural ligand acetyl-CoA), whereas the combination of amikacin and adjuvants (ZnPT, vitamin D, E, and K) significantly reduced the activity of AAC(6′)-Ib. Similar results of enzyme activity reduction by adjuvants with Kanamycin and Gentamicin combinations are presented in Supplementary Fig. S6.