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. 2020 Nov 9;11:5661. doi: 10.1038/s41467-020-19501-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Volcano plot of lipid species altered in FABP3-knockdown aged vs. control muscle. Lipid species were measured by LC-MS. The x-axis indicates logarithmic (base 2) fold abundance changes of all identified lipid species and the y-axis indicates negative logarithmic (base 10) t-test p-value. The horizontal dotted line reflects the filtering criterion (p-value = 0.05). (n = 4 mice per group) b Proportion of major lipid classes in FABP3-knockdown and control aged muscles. c–f Volcano plot of PC (c), PE (d), SM (e), LPC (f) species altered in FABP3-knockdown vs. control aged muscles. The x-axis indicates the percentage changes (FABP3KD-control-aged muscle) of lipid species and the y-axis indicates negative logarithmic (base 10) t-test p-values. The horizontal dotted line reflects the filtering criterion (p-value = 0.05). Red and green indicate highly increased and decreased lipid species, respectively. g Proportion of SFA, MUFA, or PUFA PC acyl chains in FABP3-knockdown and control-aged muscles. h Proportion of <C18, C18, or >C18 PC acyl chains in FABP3-knockdown and control-aged muscles. The data are presented as means ± S.E.M. Two-tailed unpaired Student’s t-test was used. i Correlation analysis of the total identified lipid species in the indicated comparative condition. The x-axis indicates logarithmic (base 2) fold concentration changes of all identified lipid species in FABP3-knockdown aged vs. aged muscle and the y-axis indicates logarithmic (base 2) fold changes in aged vs. young muscle. Data in i were analyzed using Spearman’s correlation; correlation coefficient (r) and p-value (p) are in red. Source data are provided as a Source Data file.