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. 2020 Oct 23;23(11):101727. doi: 10.1016/j.isci.2020.101727

Figure 2.

Figure 2

PPARα-LBD-ligand Structures Obtained Using Soaking, Cross-Seeding, and Delipidation Methods for Crystallization

(A–D) Crystal structures and magnified views of PPARα-LBD and five potent PPARα agonists obtained using soaking (A); two potent PPARα agonists obtained using cross-seeding (see also Figure S5) (B); two intermediately potent PPARα agonists obtained using co-crystallization of the delipidized proteins (C); or five exogenous fatty acids with relatively low potency obtained by cross-seeding of the delipidized proteins (D).

The electron density is shown in the mesh by Feature Enhanced Maps (FEMs) contoured at 1.0σ. PDB identities and resolutions are labeled, and water molecules are presented as cyan spheres.