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. 2020 Aug 24;3(1):100174. doi: 10.1016/j.jhepr.2020.100174

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Histological and radiological features of hepatocholangiocarcinoma.

Classical cHCC-CCA (upper panel, left) with the HCC (positive for glypican 3) and CCA (positive for CK7) components, as well as intermediate cell carcinoma (positive for CD133) (upper panel, right). HCC with stem cell features (middle panel, left) at immunohistochemistry (positive for glypican 3 and for CK19) and cholangiolocarcinoma recently reclassified as iCCA (middle panel right). An example of an MRI of cHCC-CCA with a well-delineated heterogeneous lesion with capsular retraction. The lesion harboured progressive delayed enhancing areas mixed with areas with arterial enhancement and washout. cHCC-CCA, combined hepatocholangiocarcinoma; CCA, cholangiocarcinoma; HCC, hepatocellular carcinoma.